Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure
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چکیده
منابع مشابه
Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure
The serotonin receptor 2C plays a central role in mood and appetite control. It undergoes pre-mRNA editing as well as alternative splicing. The RNA editing suggests that the pre-mRNA forms a stable secondary structure in vivo. To identify substances that promote alternative exons inclusion, we set up a high-throughput screen and identified pyrvinium pamoate as a drug-promoting exon inclusion wi...
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A-to-I RNA editing has mainly been found in various receptors and ion channels in the central nervous system, including the serotonin 2C receptor, glutamate receptor, GABA receptor, and potassium channel. Interestingly, most of them are suggested to be involved in the pathophysiology of major mental disorders such as schizophrenia, bipolar disorder, and major depression. Here we review studies ...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2013
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gkt063